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Center of Biotechnology Information\uff09\u30023D\u30d7\u30ea\u30f3\u30c6\u30a3\u30f3\u30b0\u306f\u3001\u524d\u81e8\u5e8a\u78c1\u6c17\u5171\u9cf4\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u54c1\u8cea\u3001\u52b9\u7387\u3001\u518d\u73fe\u6027\u306b\u3082\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u307e\u3059\u3002\u52d5\u7269\u306e\u53d6\u308a\u6271\u3044\u3092\u5bb9\u6613\u306b\u30ab\u30b9\u30bf\u30de\u30a4\u30ba\u3067\u304d\u3001\u89e3\u5256\u5b66\u7684\u69cb\u9020\u304a\u3088\u3073RF\u30b3\u30a4\u30eb\u306e\u4e00\u8cab\u3057\u305f\u30dd\u30b8\u30b7\u30e7\u30cb\u30f3\u30b0\u3092\u8fc5\u901f\u306b\u5b9f\u73fe\u3057\u3001\u30b9\u30eb\u30fc\u30d7\u30c3\u30c8\u3092\u52a0\u901f\u3059\u308bMR\u9069\u5408\u90e8\u54c1\u3092\u88fd\u9020\u3059\u308b\u80fd\u529b\u3092\u5927\u5e45\u306b\u62e1\u5927\u3057\u307e\u3057\u305f\u3002\u7279\u5b9a\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u7814\u7a76\u3001\u52d5\u7269\u7a2e\u3001\u52d5\u7269\u306e\u4f53\u91cd\u3001\u3042\u308b\u3044\u306f\u524d\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u65e5\u5e38\u7684\u306b\u4f7f\u7528\u3055\u308c\u306a\u3044\u30e6\u30cb\u30fc\u30af\u306a\u52d5\u7269\u306b\u30ab\u30b9\u30bf\u30de\u30a4\u30ba\u3055\u308c\u305f\u30d1\u30fc\u30c4\u3092\u3001\u8fc5\u901f\u304b\u3064\u30b3\u30b9\u30c8\u52b9\u7387\u3088\u304f\u4f5c\u6210\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002 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CRISPR\u306f\u4eca\u3084\u907a\u4f1d\u5b50\u7de8\u96c6\u306e\u9769\u547d\u7684\u6280\u8853\u3067\u3042\u308b\u3002Cas9\u9175\u7d20\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001CRISPR\u306f\u4ed6\u306e\u907a\u4f1d\u5b50\u6539\u5909\u6280\u8853\u3068\u306f\u4e00\u7dda\u3092\u753b\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u6280\u8853\u306f\u3001DNA\u306e\u640d\u50b7\u3057\u305f\u90e8\u5206\u3084\u4e0d\u8981\u306a\u90e8\u5206\u3092\u5207\u308a\u53d6\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u907a\u4f1d\u5b50\u3092\u7de8\u96c6\u30fb\u518d\u914d\u5217\u3057\u3001\u6b8b\u308a\u306eDNA\u3092\u65b0\u3057\u3044\u65b9\u6cd5\u3067\u518d\u914d\u5217\u3067\u304d\u308b\u3088\u3046\u306b\u3059\u308b\u3002\u3053\u306e\u8fc5\u901f\u304b\u3064\u6b63\u78ba\u3067\u4f7f\u3044\u3084\u3059\u3044\u6280\u8853\u306f\u3001\u7814\u7a76\u306b\u304a\u3044\u3066\u753b\u671f\u7684\u306a\u30c4\u30fc\u30eb\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u30d2\u30c8\u306b\u304a\u3051\u308b\u6cbb\u7642\u7684\u5229\u7528\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u306b\u5f37\u3044\u95a2\u5fc3\u304c\u5bc4\u305b\u3089\u308c\u3066\u3044\u308b\u3002CRISPR\u306f\u30de\u30a6\u30b9\u3084\u30d2\u30c8\u306e\u7d30\u80de\u3067\u4f7f\u7528\u3055\u308c\u3001\u3059\u3067\u306b\u69d8\u3005\u306a\u751f\u7269\u5b66\u7684\u30b7\u30b9\u30c6\u30e0\u3084\u75be\u60a3\u9818\u57df\u306b\u5fdc\u7528\u3055\u308c\u3066\u3044\u308b\u3002\u539f\u6838\u751f\u7269\u306e\u9069\u5fdc\u514d\u75ab\u7cfb\u306b\u7531\u6765\u3059\u308bCRISPR\uff08clustered, regularly interspaced short palindromic repeats\uff09\u30b7\u30b9\u30c6\u30e0\u306f\u3001\u69d8\u3005\u306a\u7814\u7a76\u306b\u5fdc\u7528\u3067\u304d\u308b\u753b\u671f\u7684\u306a\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3067\u3042\u308b\u3002CRISPR\u306f\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30de\u30a6\u30b9\u7cfb\u7d71\u306e\u958b\u767a\u306b\u4f7f\u7528\u3055\u308c\u3001\u305d\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u8fc5\u901f\u5316\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u4f4e\u30b3\u30b9\u30c8\u5316\u3082\u5b9f\u73fe\u3057\u3066\u3044\u308b\u3002  \u8ab2\u984c\uff1a\u4ee3\u66ff\u52d5\u7269\u5b9f\u9a13\u6cd5\u306e\u958b\u767a 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Jackson Laboratory\u793e\uff08\u7c73\u56fd\uff09\u3001Inotiv\u793e\uff08\u7c73\u56fd\uff09\u3001genOway\u793e\uff08\u30d5\u30e9\u30f3\u30b9\uff09\u3001Taconic Biosciences, Inc.\u793e\uff08\u7c73\u56fd\uff09\u306a\u3069\u304c\u3042\u308b\u3002  2022\u5e74\u306e\u30de\u30a6\u30b9\u6a21\u578b\u5e02\u5834\u3067\u306f\u3001\u6a21\u578b\u30bf\u30a4\u30d7\uff06\u30b5\u30fc\u30d3\u30b9\u5206\u91ce\u3067\u6a21\u578b\u30bf\u30a4\u30d7\u304c\u6700\u5927\u306e\u30b7\u30a7\u30a2\u3092\u5360\u3081\u305f\u3002 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